Welcome to the Membrane Protein Structural Biology Consortium
Structure of the integral membrane protein CaaX protease (Ste24p) from Saccharomyces mikatae.  Mutations in the human ortholog of Ste24p are linked to premature aging in children, and interactions of Ste24p with certain AIDS medications may lead to treatment side effects.  [Learn more]

PSI logo MPSBC is one of 9 membrane protein structure determina- tion centers established in July 2010 as part of the NIGMS PSI:Biology Initiative.

MPSBC's Mission:
MPSBC aims to establish a pipeline to generate multiple target constructs for expression studies followed by pre-crystallization screening to identify stable protein:detergent complexes. The complexes then undergo high-throughput crystallization screening and optimization followed by structure determination. Targets include transporters, transmembrane enzymes involved in lipid synthesis and lipid attachment, and membrane protein complexes.

Community Outreach:
MPSBC offers assistance with protein production, pre-crystallization screening, and high-throughput crystallization.

Contact MPSBC:
Dr. Michael Malkowski, Hauptman-Woodward Medical Research Inst. 700 Ellicott Street, Buffalo, NY 14203-1102. Tel: 716 898 8624

MPSBC is supported by NIH/NIGMS Grant GM094611.